中国比较医学杂志Issue(10)：78-81,89,5.DOI:10.3969/j.issn.1671.7856.2014.010.015
TRPV1和 ASIC3基因敲除小鼠的寿命观察
Survival analysis of ASIC3 -/-and TRPV1 -/-mice
摘要
Abstract
Objective To analyze the survival curves of ASIC3 -/-and TRPV1 -/-mice, and provide a reference for further breeding of these strains of mice.Methods Forty-four ASIC3 -/-mice and sixty-one TRPV1 -/-mice were included in this study.The survival of the mice was observed in normal feeding for 500 days, survival curves were drawn, and their survival was analyzed.Results With the passing of time, the survival probability was decreased in ASIC3 -/-mice and TRPV1 -/-mice.The survival probability of TRPV1 -/-mice was significantly better than that of ASIC3 -/-mice (P =0.004, P <0.01).No significant difference was observed between the males and females of the same strain. Conclusions The survival probability of TRPV1 -/-mice is better than that of ASIC3 -/-mice.There is no significant gender difference in the two strains of mice.关键词
ASIC3 -/-/TRPV1 -/-/生存分析/小鼠/基因敲除Key words
ASIC3 -/-, mice/TRPV1 -/-, knockout/Survival analysis/Mice分类
医药卫生引用本文复制引用
石宏,张毅,景向红,何伟,王晓宇,胡玲,宿杨帅,辛娟娟,杨兆坤,韩旭,高洁..TRPV1和 ASIC3基因敲除小鼠的寿命观察[J].中国比较医学杂志,2014,(10):78-81,89,5.基金项目
国家自然科学基金项目 （）
国家重点基础研究发展计划（973计划）（2011CB505201）。 （）
