中国比较医学杂志Issue(11)：1-5,5.DOI:10.3969/j.issn.1671.7856.2014.011.001
Fah －／－小鼠对 NTBC 的药物依赖性观察
To observe the NTBC dependence of Fah-knockout mice
摘要
Abstract
Objective To observe the NTBC dependence of Fah-knockout mice and study the biological characteristics in order to use the model more effectively.Methods Examine the progressive changes in body weight, survival time, liver pathology and serological markers after the NTBC withdrawal.Results After removing of NTBC, Fah-knockout mice lost their body weight gradually, and finally died in 5 to 7 weeks, along with increased serum ALT, AST levels and deformation of the hepatocytes.Conclusions Fah-knockout mice have a strong drug dependence of NTBC and could be the ideal model to hereditary tyrosinemia type I and other liver injury.关键词
Fah-/-小鼠/NTBC/肝损伤/酪氨酸血症Ⅰ型Key words
Fah-knockout mice/NTBC/Liver failure/Tyrosinemia type I分类
医药卫生引用本文复制引用
彭雨婷,武昕,孔祥平,李绍林,刘光泽..Fah －／－小鼠对 NTBC 的药物依赖性观察[J].中国比较医学杂志,2014,(11):1-5,5.基金项目
国家973重点基础研究发展计划（2010CB945502）。 （）
