中国比较医学杂志Issue(1)：15-19,5.DOI:10.3969/j.issn.1671.7856.2015.001.003
应用遥测技术对 SHR 大鼠血压、心率变异性月龄动态变化和性别差异的研究
Study on dynamic changes and gender difference of heart rate variability and blood pressure variability via implantable telemetry technology in spontaneously hypertensive rats
摘要
Abstract
Objective To observation dynamic changes and gender difference of heart rate variability and blood pressure variability in unbonded spontaneously hypertensive rats using Telemetry technology .Method Taking sixteen spontaneously hypertensive rats of 3-month-old in SPF grade, there were implanted TL11M2-C50-PXT device intraperitoneally.Seven days later, respectively monitoring chainless blood pressure and electrocardiogram for 24 h continuously time using telemetry system when 3, 5, 7 months of age in spontaneously hypertensive rats .Analysing 24 h systolic pressure , mean blood pressure , diastolic blood pressure , heart rate variability and blood pressure variability . Result Systolic pressure , diastolic pressure and mean pressure , blood pressure variability increased with age of the moon increased in spontaneously hypertensive rats , moreover female SHR rats of blood pressure variability was significantly lower than that of the male rats .Correlated indexes of heart rate variability had no obvious change Between three to seven month -old in male spontaneously hypertensive rats .But RR interval , SDNN, TP, VLF and HF increased significantly with age of the moon increased in female spontaneously hypertensive rats , moreover the female SHR rats of TP , VLF and HF index of heart rate variability were lower than the male rats .Conclusion With the SHR rats age and blood pressure , blood pressure variability increased , and the female SHR rat variability in blood pressure and heart rate was significantly lower than that of the male .关键词
遥测技术/自发性高血压大鼠/血压变异性/心率变异性Key words
Telemetry/Spontaneously hypertensive rat/Heart rate variability/Blood pressure variability分类
医药卫生引用本文复制引用
张利棕,潘水珍,周卫民,潘永明,徐孝平,寿旗扬,陈民利..应用遥测技术对 SHR 大鼠血压、心率变异性月龄动态变化和性别差异的研究[J].中国比较医学杂志,2015,(1):15-19,5.基金项目
国家自然科学基金项目（81202972）；浙江省公益性技术应用研究计划（2014C37012、2011C37076）；国家级大学生创新创业训练计划项目（201310344001）。 （）
