中国比较医学杂志Issue(4)：8-13,6.DOI:10.3969/j.issn.1671.7856.2015.004.002
脑卒中后抑郁大鼠行为学的动态变化及中药补阳还五汤的干预作用
Dynamic changes of ethology and interventional effect of a traditional Chinese medicine,BuyangHuanwu Decoction, in rats with post-stroke depression
摘要
Abstract
Objective To observe the effect of a traditional Chinese medicine, BuyangHuanwu Decoction, on the ethology in rat models of post-stroke depression ( PSD) .Methods Sixty male SD rats, after open-field ethology scoring, were randomly divided into five groups ( 12 rats in each group):sham operation group, cerebral ischemic stroke group, post-stroke depression ( PSD) group, BuyangHuanwu Decoction group, and fluoxetine group.The rat PSD models were established with separately breeding and chronic unpredictable moderate stress ( CUMS ) after middle cerebral artery occlusion. Behavior changes of the rats were detected by body weight measurement, neurological scoring, sugar consumption test and open-field test.Results Compared with the sham operation group and cerebral ischemic stroke group, the body weight,sugar consumption and open-field spontaneous activity in the PSD model group were decreased, and the neurological function deficits became more severe ( P <0.01 or P <0.05 ) .Compared with the PSD group, Both BuyangHuanwu Decoction group and fluoxetine group got significantly higher scores of body weight,sugar consumption and spontaneous activity,and improved neurological function deficits(P<0.01 or P<0.05).Conclusions PSD rats exhibit abnormal behavior.BuyangHuanwu Decoction can significantly improve the behavioral impairment of PSD rats. The antidepressant effect of BuyangHuanwu Decoction is comparable to that of fluoxetine in the treatment of PSD rats.关键词
补阳还五汤/卒中后抑郁/行为学/大鼠Key words
BuyangHuanwu decoction/Post-stroke depression/Behavior/Rats分类
医药卫生引用本文复制引用
罗琳,邓叔华,易健,周赛男,佘颜,刘柏炎..脑卒中后抑郁大鼠行为学的动态变化及中药补阳还五汤的干预作用[J].中国比较医学杂志,2015,(4):8-13,6.基金项目
国家自然科学基金（编号81273989）；湖南省高校创新平台开放基金项目（12K089）；湖南中医药大学病理学与病理生理学重点学科（2012）。 （）
