中国比较医学杂志Issue(4)：27-32,6.DOI:10.3969/j.issn.1671.7856.2015.004.006
人参皂苷水解产物 DS－1227改善东莨菪碱致小鼠的学习记忆障碍
Improving effect of the ginsenoside hydrolysis product DS-1227 on scopolamine-induced learning and memory impairment in mice
摘要
Abstract
Objective The aim of this experiment was to study the improving effects of a ginsenoside hydrolysis product DS-1227 on scopolamine-induced learning and memory impairment in mice.Methods Sixty healthy 5-6-week old male ICR mice (body weight 22 ±2 g) were randomly divided into control group, model group, three DS-1227 groups (25 mg/kg, 50 mg/kg, 100 mg/kg), and positive control group (0.3 mg/kg).Fourteen days after oral administration of DS-1227, an open-field test was conduct to determine the mouse locomotor activity.Fifteen days after oral administration of DS-1227, all experimental animals were intraperitoneally administered scopolamine (0.75 mg/kg) and the mice of control group received the same volume of saline.In addition to scopolamine, the mice of positive control group received intraperitoneal injection of physostigmine in a dose of 0.3 mg/kg.Twenty minutes after completion of all the drug administration, object recognition test and Morris water maze test were conducted to evaluate the learning and memory abilities of the mice.Results DS-1227 had no significant effect on locomotor activity of the mice.Scopolamine obviously decreased the discrimination indexes in object recognition test, and prolonged the escape latency of water maze place navigation test.While 25 mg/kg, 50 mg/kg, 100 mg/kg of DS-1227 increased the discrimination indexes and decreased the escape latency of place navigation in the mice.Conclusion DS-1227 can improve the learning and memory impairment induced by scopolamine in mice.关键词
DS-1227/东莨菪碱/学习记忆障碍Key words
Ginsenoside hydrolysis product DS-1227/Scopolamine/Learning and memory impairment/Mice分类
医药卫生引用本文复制引用
武宏伟,王克柱,冯利,卢聪,徐攀,廖永红,曲丽娜,李莹辉,刘新民..人参皂苷水解产物 DS－1227改善东莨菪碱致小鼠的学习记忆障碍[J].中国比较医学杂志,2015,(4):27-32,6.基金项目
重大新药创制（编号2012ZX09J12110－04C）；国际科技合作专项（编号2011DFA32730）；全军医学科技“十二五”科研项目（编号BWS11J052）。 （）
