中国比较医学杂志Issue(5)：9-12,4.DOI:10.3969/j.issn.1671.7856.2015.005.003
探讨姜黄素和茶多酚对不同时间 UVB致无毛鼠急性光损伤的防御作用
Protective effect of Curcumin and Tea Polyphenols against different time of UVB-induced acute photodamage in hairless mice skin
摘要
Abstract
Objective To assess the protective of Curcumin and Tea Polyphenols against different time of UVB-induced acute photo damage in hairless mice skin.Methods Thirty six BALB/C hair1ess mice were randomly divided into control groups and treatment groups(all of them were divided into 0 s, 30 s, 60 s, 120 s, 240 s groups with two hairless mice).Curcumin and Tea Polyphenols were applied to the mice’s skin before 30min irradiation.The irradiation distance was 15cm.The mice in each group were given three times of UVB MED about 200 ~540 mJ/cm 2 and the irradiation time were 30 s、60 s、120 s、240 s.After irradiation, the skin on the back of the radiation center were taken into paraffin section for light microscopy observation.Results Different amount of squamae appeared in the control group of hairless rat, and lymphocytes scattered in collagen tissues.In the 120 s and 240 s UVB irradiated group, the collagen was red stained, disorderly arranged, even homogenized.In the treatment group, inflammatory cell infiltration was lessened, and collagen damage weakened.Conclusion By weakening inflammatory cell infiltration and collagen damage, topical application of Curcumin and Tea Polyphenols can protect hairless mice from acute photodamage caused by UVB irradiation.关键词
UVB/无毛鼠/模型,动物/光损伤Key words
UVB/Hairless mice/Model,animal/Photo damage分类
医药卫生引用本文复制引用
高爱莉,李润祥,马少吟,李振洁,龚业青,朱慧兰,江娜,刘清,张倩雯,范君文,王鹏,邓蕙妍,田歆,梁碧华..探讨姜黄素和茶多酚对不同时间 UVB致无毛鼠急性光损伤的防御作用[J].中国比较医学杂志,2015,(5):9-12,4.基金项目
2013年广州市医药卫生科技项目（20131A011131）；2013年广东省科技计划项目（2013B021800044）；2014年广东省医学科研基金（A2014592）；“十二五”专项课题（2011ZXJ09201－031）。 （）
