中国比较医学杂志Issue(7)：77-80,4.DOI:10.3969/j.issn.1671.7856.2015.007.017
多发性硬化症信号传导通路异常研究进展
Progress of signaling pathways abnormal in multiple sclerosis
摘要
Abstract
The pathogenesis of multiple sclerosis ( MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing more-effective therapies.In MS, abnormalities have been identified in several cytokine-signaling pathways, as well as those of other immune receptors.Among the downstream molecules implicated are Jak/Stat, NF-κb, ERK1/2, p38 or Jun/Fos, current MS drugs target some of these pathways.This article will with the aid of the latest research results of systems biology approaches that study pathway dysregulation in the process of MS development, targeting these relevant MS-signaling pathways, offers the opportunity to accelerate the development of novel individual or combination therapies for the future of new drug research.关键词
多发性硬化症/信号传导通路/药物研发Key words
Multiple sclerosis/Signaling pathways/Drug research and development分类
医药卫生引用本文复制引用
郑娜,王奇,尹琳琳..多发性硬化症信号传导通路异常研究进展[J].中国比较医学杂志,2015,(7):77-80,4.基金项目
国家自然科学基金项目（81341088；81273817）；北京市科技新星计划（Z12111000250000）。 （）
