中国动物传染病学报Issue(4)：72-80,9.
RNA病毒感染对应激颗粒的调控作用
REGULATION OF STRESS GRANULES DURING RNA VIRUS INFECTION
摘要
Abstract
Stress granules (SGs) are reversible dynamic structures that rapidly form when mammalian cells encounter environmental stress like heat shock, oxidative, nutrient deprivation, or viral infection, which can reduce global translation rates. As the complexes of stalled translation factor, SGs play major roles in gene expression and homeostasis. When virus infects host cells, the formation of SGs can greatly reduce the level of protein translation, thereby inhibit viral replication. Yet simple viruses have evolved efficient means to resist the stress responses, some of them even can use the silent transcripts involved in SGs to increase their replication. This review covers the range of interactions between RNA viruses and SGs and discusses the newly described interactions between stress responses and innate immune responses.关键词
应激颗粒/RNA病毒/调控机制/先天性免疫Key words
Stress granules/RNA virus/regulation system/innate immune分类
农业科技引用本文复制引用
王晓旭,孙英杰,丁云磊,王桂军,丁铲..RNA病毒感染对应激颗粒的调控作用[J].中国动物传染病学报,2014,(4):72-80,9.基金项目
863计划（2011AA10A209）；公益性行业(农业)科研专项 （农业）
