中国动物传染病学报Issue(5)：72-79,8.
RIG-I样受体信号通路及其调控研究进展
ADVANCES IN SIGNALING PATHWAYS AND REGULATION OF RIG-I-LIKE RECEPTOR
摘要
Abstract
The RIG-I-like receptors (RLRs) family of pattern recognition receptors (PRRs) is a group of cytosolic RNA helicase proteins that can identify viral RNA as non-self via binding to pathogen associated molecular pattern (PAMP) motifs within RNA ligands. This interaction then leads to triggering of an innate antiviral response within the infected cells through RLR induction of downstream effector molecules such as type I interferon (IFN) and other proinflammatory cytokines that serve to induce antiviral and inflammatory gene expression. In this paper, the composition of the RLR signaling pathway and regulation of ubiquitination reaction are described briefly. The mechanisms of viruses targeting RLR pathways to escape from the immune response are also summarized. Furthermore, the signaling crosstalk between RLR pathways and NOD-like receptor (NLR) pathways are introduced. Understanding the pivotal role of RLRs in immune regulation and signaling crosstalk in antiviral immunity may provide new insights into therapeutic strategies for the control of virus infection and immunity.关键词
RIG-I样受体/先天性免疫/细胞信号转导/病毒感染Key words
RIG-I-like receptors/innate immunity/cell signaling/viral infection分类
农业科技引用本文复制引用
丁云磊,孙英杰,王晓旭,胡跃,费荣梅,丁铲..RIG-I样受体信号通路及其调控研究进展[J].中国动物传染病学报,2014,(5):72-79,8.基金项目
863计划（2011AA10A209）；公益性行业(农业)科研专项 （农业）
