中国动物传染病学报2015，Vol.23Issue(3)：73-80,8.
寄生虫潜在药物靶标—乳酸脱氢酶
A POTENTIAL DRUG TARGET FOR PARASITES—LACTATE DEHYDROGENASE
摘要
Abstract
Parasites include protozoon, trematodes, cestodes, nematode, acanthocephalan and so on, which cause diseases in human beings and animals. The misuse of antihelmintics has led to wide and serious drug-resistance. Therefore, there is an extremely urgent need for development of new drugs. Lactate dehydrogenase (LDH) acts as the terminal enzyme on glycolytic pathway and catalyzes the reversible reaction of pyruvate to lactate. In the process of this metabolic pathway, NADH and NAD+ serve as coenzymes thus the energy resources are generated for parasites. This article summarizes the methods used in studying antiparasitic drug targets and progress in research on LDH as a potential drug target for parasites, representing important theoretical signifi cance in the research on the molecular mechanisms of drugs and development of new drugs.关键词
寄生虫/抗寄生虫药物/药物靶标/乳酸脱氢酶Key words
Parasites/antiparasitic drug/drug targets/lactate dehydrogenase分类
农业科技引用本文复制引用
李莎,董辉,黄兵..寄生虫潜在药物靶标—乳酸脱氢酶[J].中国动物传染病学报,2015,23(3):73-80,8.基金项目
国家自然科学基金(31272557) （31272557）
