中国实用外科杂志Issue(8)：762-764,3.DOI:10.7504/CJPS.ISSN1005-2208.2014.08.24
FOLFOX4方案系统性化疗治疗进展期肝细胞癌22例疗效分析
Efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma：An analysis of 22 cases
殷晓煜 1陈洁 2彭建新 3陈伟 3杨秋辰 2刘鑫 1张昆松 1梁力建1
作者信息
- 1. 中山大学附属第一医院 肝胆外科
- 2. 中山大学附属第一医院消化内科，广东广州510080
- 3. 广东省中医院肝胆外科，广东广州510120
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma (HCC). Methods The clinical data of 22 cases of advanced HCC were treated by FOLFOX4 regimen systemic chemotherapy between July 2007 and July 2013 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The chemotherapy was given each two weeks,with a maximum of 8 cycles. The therapeutic responses were evaluated each 3 cycles and end of treatment. Results A total of 85 cycles were administered in 22 cases,with a mean of(3.7±2.0)cycles/case. There were no complete response,5 partial responses,5 static diseases and 12 progressive diseases. The objective response rate was 22.7%(5/22),and disease control rate was 45.4%(10/22),with a one-year survival rate of 12.1%and median survival time of 5.8 months in the follow up of 2-34 (8.5±1.9)months . In 10 cases of disease control after chemotherapy,the median survival time reached up to 9.5 months. Conclusion FOLFOX4 regimen systemic chemotherapy is effective in part of advanced HCC,and represented as an effective modality.关键词
肝细胞癌/进展期/化学治疗/FOLFOX4方案Key words
hepatocellular carcinoma/advanced stage/chemotherapy/FOLFOX4 regimen分类
医药卫生引用本文复制引用
殷晓煜,陈洁,彭建新,陈伟,杨秋辰,刘鑫,张昆松,梁力建..FOLFOX4方案系统性化疗治疗进展期肝细胞癌22例疗效分析[J].中国实用外科杂志,2014,(8):762-764,3.
