中国实用外科杂志Issue(12)：1179-1182,4.DOI:10.7504/CJPS.ISSN1005-2208.2014.12.22
胰腺癌病人心率变异性变化及其临床意义研究（附518例分析）
Clinical significance of heart rate variability change in pancreatic cancer patients:An analysis of 518 cases
陈海华 1钱能 1丁国平 1吴峥嵘 1庞天舒 1曹利平1
作者信息
- 1. 浙江大学医学院附属第二医院肝胆胰外科，浙江杭州310009
- 折叠
摘要
Abstract
Objective To evaluate the clinical value of heart rate variability change in the patients with pancreatic cancer. Methods The clinical data of 518 cases of pancreatic cancer admitted from January 2008 to May 2013 in the Second Affiliated Hospital of Zhejiang University School of Medicine were analyzed retrospectively. The moderating effects of gender,age,cancer stages and distant metastasis on HRV including standard diviation of NN intervals (SDNN) and root mean square of successive differences(RMSSD)were examined. The statistical significance of C-ractiveprotein (CRP)and tumor diameter between low HRV group and high HRV group using the cut-off of SDNN=20ms were tested. Results HRV values in cancer patients with early stage was higher than those with advanced stages significantly (P<0.001). HRV values in cancer patients without metastasis had significant higher HRV than those with metastases (P=0.011). CRP was higher in low HRV group than that in high HRV group(P=0.008). Conclusion The later the stage of pancreatic cancer patients is,the more the index of HRV declines, which may be related to the mechanism that vagal nerve excitement inhibits inflammatory reaction.关键词
胰腺癌/心率变异性/迷走神经/C反应蛋白Key words
pancreatic cancer/HRV/vagal nerve/CRP分类
医药卫生引用本文复制引用
陈海华,钱能,丁国平,吴峥嵘,庞天舒,曹利平..胰腺癌病人心率变异性变化及其临床意义研究（附518例分析）[J].中国实用外科杂志,2014,(12):1179-1182,4.
