中国听力语言康复科学杂志Issue(2)：117-119,3.DOI:10.3969/j.issn.1672-4933.2015.02.009
盐酸椒苯酮胺对豚鼠耳蜗缺血再灌注损伤后细胞凋亡的影响
Effect by Piperphentonamine Hydrochloride on Apoptosis in Cochlea of Guinea Pigs with Ischemia Reperfusion Injury
摘要
Abstract
Objective To investigate the protection by piperphentonamine hydrochloride(PPTA) on apoptosis in cochlear of guinea pigs with Ischemia Reperfusion Injury(I/RI).Methods 24 healthy guinea pigs were randomly devided into the normal group,negative control group,I/RI group in which the cochlea of guinea pigs were apoptotic for I/RI, and PPTA group in which PPTA was injected into guinea pigs whose cochlea were with I/RI. Each group had 6 guinea pigs . The cell apoptosis of guinea pigs in every group was studied by TUNEL method.The difference between the groups was analyzed by apoptotic index (AI).Results No or few cell apoptosis was observed in cochlea in the normal group, control group and PPTA group . The cochlea apoptotic cells increased obviously in the I/RI group than the other three groups.PPTA could significantly reduce the apoptotic cells.Conclusion Apoptosis is a form of damage to the cochlea with I / RI.The therapy of PPTA may prevent the cochlea from I / RI by reducing apoptosis.关键词
缺血再灌注损伤/细胞凋亡/盐酸椒苯酮胺Key words
Ischemia-reperfusion injury(I/RI)/Apoptosis/Piperphentonamine hydrochloride(PPTA)引用本文复制引用
汪志伟,杨海弟,李永贺,吴剑,李威..盐酸椒苯酮胺对豚鼠耳蜗缺血再灌注损伤后细胞凋亡的影响[J].中国听力语言康复科学杂志,2015,(2):117-119,3.基金项目
广东省教育部产学研结合项目 （）
