中国听力语言康复科学杂志Issue(3)：198-201,4.DOI:10.3969/j.issn.1672-4933.2015.03.009
线粒体DNA 1555/1494突变耳聋文献回顾
The Meta Analysis of Carrying mtDNA A1555G/C1494T Mutation
摘要
Abstract
Objective Clinical characteristics of deaf patients caused by mitochondrial DNA (mtDNA) 1555 /1494 mutations are not clearly defined. Here we review the relative literature to summarize the audiological characteristics of these patients and to discuss the factors affecting hearing loss degree.Methods We have selected “mtDNA 1555/1494 mutation” and “sensorineural hearing loss” as keywords to search for the data in the databases of CNKI , WanFang, VIP, and PubMed. From the resources, we collected the data, including the basic information, audiological records, genetic information, and medication. The literature review was conducted with the software of EXCEL and SPSS 19.0.Results Among the collected 324 cases from 39 publications, 285 cases carrying mtDNA 1555 mutation include 254 Chinese,18 other Asians and 13 non-Asians, and all the 39 cases carrying mtDNA C1494T mutation are Chinese. 230 cases had the specific history of using aminoglycoside antibiotic and 92 cases did not. However, two of them can hear normally one year later. A statistical analysis suggested that the degree of hearing loss in patients with treatment was significantly severer than patients without(X2=25.414,P<0.05). Whether being treated or not, the patients’ ages of onset had a significant negative correlation with the degree of hearing loss(P<0.05). But there were no correlations between the onset of intervals and the degree of hearing loss(R=0.054,P>0.05). In addition, the heterogeneous mutation rate and the degree of deafness had a significant positive correlation (R=0.823,P<0.05). Conclusion A variety of factors influence the clinical features of mtDNA A1555G/C1494T carriers. Genetic diagnosis plays an important role in valuating mtDNA A1555G/C1494T mutation related deafness. For mtDNA A1555G/C1494T mutation carriers, the use of aminoglycoside antibiotics should be banned in their lifetime.关键词
线粒体突变/耳聋/文献回顾Key words
Mitochondrial mutation/Deafness/Meta analysis引用本文复制引用
丁志伟,刘玉和..线粒体DNA 1555/1494突变耳聋文献回顾[J].中国听力语言康复科学杂志,2015,(3):198-201,4.基金项目
国家自然科学基金面上项目 （）
