摘要
Abstract
Objective To estimate the effect of nebulized magnesium sulfate on treating children with acute asthma. Methods Electronic literature search was performed up to July 2014 at the Cochrane Library,PubMed,EMBASE,CBM,CNKI,VIP and Wanfang database. The randomized controlled trails( RCTs)of nebulised magnesium sulphate for treating acute asthma in children were obtained,including the use of nebulized MgSO4 combined with bronchodilators and compared with the use of bronchodilators. The pulmonary function and adverse drug reaction were selected as primary and secondary outcomes. Data were pooled using random effects meta-analysis of the standardized mean difference( SMD)in pulmonary function by RevMan software. The subgroup analysis was performed for each pulmonary function parameter and magnesium sulfate nebulized with and without other bronchodilators. Results A total of 8 RCTs involving 1 161 patients were included. ①Nebulized MgSO4 had no significant effect upon respiratory function(10 min:SMD= _0. 32,95%CI:_0. 67 to 0. 04,P=0. 08;20 min:SMD= _0. 11,95%CI:_0. 40 to 0. 17,P=0. 43)in children. ②Subgroup analysis:MgSO4 was significantly inferior to salbutamol upon pulmonary function when compared with salbutamol(10 min:SMD= _0. 75,95%CI:_1. 29 to _0. 22,P=0. 005;20 min:SMD= _0. 46,95%CI _0. 72 to _0. 20,P=0. 006);MgSO4 didnˊt show significant effect upon respiratory function( FEV1 %predicted,PEF %predicted)to saline when used in combination with bronchodilators(FEV1% predicted after 10 min:SMD= _0. 03,95%CI:_0. 52 to _0. 46, P=0. 89;PEF% predicted after 10 min:SMD= _0. 02,95%CI:_0. 23 to 0. 19,P =0. 83;FEV1% predicted after 20 min:SMD=0. 04,95%CI:_0. 29 to 0. 37,P=0. 81;PEF% predicted after 20 min:SMD=0. 05,95%CI:_0. 31 to 0. 42,P=0. 78 ). ③Common adverse drug reaction of MgSO4 ,such as arrhythmia,decrement of myotasis reflex were not reported in included 8 studies. There was no difference in incidence of adverse drug reaction between MgSO4 and control groups. Conclusion The use of nebulized MgSO4 in the treatment of acute asthma appears to be less benefit upon improving pulmonary function in children when compared with salbutamol,and to be without significant effect upon improving pulmonary function compared with salbutamol.关键词
硫酸镁/雾化/哮喘/儿童/Meta分析/随机对照试验/肺功能Key words
Magnesium sulfate/Nebulized/Asthma/Chlidren/Meta-analysis/Randomized controlled trial/Pulmonary function
