中国药房Issue(18)：2503-2505,3.DOI:10.6039/j.issn.1001-0408.2015.18.20
注射用哌拉西林钠他唑巴坦钠致药物热的临床分析
Clinical Analysis of Drug Fever Induced by Piperacillin Sodium and Tazobactam Sodium for Injection
郑新 1路玫2
作者信息
- 1. 玉林市妇幼保健院药剂科，广西玉林 537000
- 2. 广西壮族自治区人民医院药学部，南宁530021
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for the timely and accurate judgment of drug fever induced by Piperacillin sodi-um and tazobactam sodium for injection and rational drug use in the clinic. METHODS:The medication,clinical manifestations, laboratory examination results and the physician treatment of 30 inpatients with drug fever induced by Piperacillin sodium and tazo-bactam sodium for injection from Sept. 2013 to Sept. 2014 were analyzed retrospectively and statistically. RESULTS:Most of the drug fever induced by Piperacillin sodium and tazobactam sodium for injection occurred in continuous 7 to 14 d medication,and the cumulative dosages were between 1.3 to 2.7 g/kg;73.3% of the 30 patients had fever during the intravenous drip,with body temperature mainly≥38.5 ℃;the elevation of eosinophil and slightly increase of serum C-reactive protein (CRP) and blood cell sedimentation rate (ESR) could be used as observation indexes of drug fever,but the leucocyte reduce could’t be suitable;the body temperature dropped to normal within 24 to 48 hours after stopped using it. CONCLUSIONS:The drug fever induced by Piperacillin sodium and tazobactam sodium for injection has no correlation with the patients’gender or age,and no special diagnos-tic criteria. But it has certain correlation with duration of medication,cumulative days and dosages and it can be used as reference of judgment with the combination of hematological examination index. Clinicians should improve the understanding and attention about drug fever to stop using suspicious drug in time.关键词
注射用哌拉西林钠他唑巴坦钠/药物热/药品不良反应Key words
Piperacillin sodium and tazobactam sodium for injection/Drug fever/Adverse drug reaction分类
医药卫生引用本文复制引用
郑新,路玫..注射用哌拉西林钠他唑巴坦钠致药物热的临床分析[J].中国药房,2015,(18):2503-2505,3.
