中国药房Issue(18)：2513-2516,2517,5.DOI:10.6039/j.issn.1001-0408.2015.18.23
辛伐他汀对比普伐他汀治疗高脂血症疗效和安全性的Meta分析
Meta-analysis of the Efficacy and Safety of Simvastatin vs. Pravastatin in the Treatment of Hyperlipidemia
摘要
Abstract
OBJECTIVE:To systematically evaluate the efficacy and safety of simvastatin vs. pravastatin in the treatment of hy-perlipidemia,and provide evidence-based reference for the clinical treatment. METHODS:PubMed,Medline,EMBase,Cochrane Library and CJFD were retrieved to collect the randomized controlled trial(RCT)of efficacy and safety of simvastatin(test group) and pravastatin (control group) in the treatment of hyperlipidemia. The methodological quality of included studies was evaluated. The Rev Man 5.2 software was chosen for data analysis. RESULTS:14 RCT involving 1 019 patients were included. Meta-analysis showed that simvastatin had more significant effect in the decreasing of TC [MD=-0.34,95%CI(-0.52,-0.16),P<0.001] and LDL-C[MD=-0.31,95%CI(-0.45,-0.17),P<0.001] than pravastatin;and simvastatin and pravastatin had the similar effect in TG[MD=-0.06,95%CI(-0.18,0.05),P=0.28)] and HDL-C[MD=0.00,95%CI(-0.04,0.04),P=0.85]. Adverse drug reaction rate results showed they were similar[OR=0.70,95%CI(0.36,1.39),P=0.31]. CONCLUSIONS:Simvastatin is more effective in lipid-lowering than pravastatin with similar safety. Due to the limited number and low quality of included studies,it remains to be further verified with more reasonably designed,multi-center and large-sample studies.关键词
辛伐他汀/普伐他汀/高脂血症/Meta分析/疗效/安全性Key words
Simvastatin/Pravastatin/Hyperlipidemia/Meta-analysis/Efficacy/Safety分类
医药卫生引用本文复制引用
刘一,张春燕,陈月,黄婧,冯婉玉..辛伐他汀对比普伐他汀治疗高脂血症疗效和安全性的Meta分析[J].中国药房,2015,(18):2513-2516,2517,5.基金项目
国家卫生和计划生育委员会药物政策与基本药物制度司委托课题 （）
