中国药房Issue(18)：2559-2561,3.DOI:10.6039/j.issn.1001-0408.2015.18.39
氧氟沙星凝胶微生物限度检查方法研究
Research on the Method of Microbial Limit Test for Ofloxacin Gel
毛腾霄 1熊雯 1秦玉花2
作者信息
- 1. 成都市食品药品检验研究院，成都 610041
- 2. 成都中医药大学基础医学院，成都 610072
- 折叠
摘要
Abstract
OBJECTIVE:To establish a method of microbial limit test for Ofloxacin gel. METHODS:Test sample solutions were prepared by MnSO4,CaCl2 and MgCl2 gelout with different concentrations,the numbers of bacteria and control bacteria were detected by membrane filtration method,and the numbers of molds and yeasts were determined by conventional method. RE-SULTS:The conventional method showed the recoveries of Candida albicaus and Aspergillus niger were more than 70% after not treated by gel breaker;the membrane filtration method showed the recoveries of Escherichia coli,Staphylococcus aurus and Baci-lus subtilis were more than 70% after treated by 5% MnSO4,3% CaCl2 and 1% MgCl2;the membrane filtration method could de-tect the control bacteria after treated by gel breaker. CONCLUSIONS:Gel breaker with appropriate concentrations can effectively eliminate the antibacterial activity of Ofloxacin gel. The established method is suitable for its microbial limit test.关键词
氧氟沙星凝胶/微生物限度检查/破胶剂/薄膜过滤法Key words
Ofloxacin gel/Microbial limit test/Gel breaker/Membrane filtration method分类
医药卫生引用本文复制引用
毛腾霄,熊雯,秦玉花..氧氟沙星凝胶微生物限度检查方法研究[J].中国药房,2015,(18):2559-2561,3.
