中国药房Issue(21)：2899-2900,2901,3.DOI:10.6039/j.issn.1001-0408.2015.21.07
阿普唑仑渐进式加量治疗慢性耳鸣的疗效与安全性观察Δ
Observation on the Efficacy and Safety of Alprazolam by Progressive Dose Increasing in the Treatment of Chronic Tinnitus
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of alprazolam by progressive dose increasing in the treatment of chronic tinnitus. METHODS:Totally 50 patients with chronic tinnitus were included. They were orally treated with Alprazolam tab-let 0.4 mg in the first 1 and 2 week(s),once every night at bedtime;0.4 mg in 3 and 4 weeks,once in the morning and once in the evening;0.4 mg in 5 and 6 weeks,three times a day. If the treatment of tinnitus was invalid,then the gradual withdrawl was conducted by twice a day for continuous 3 d,0.4 mg each time;then once a day,0.4 mg each time,for continuous 3 d. The re-sponders were maintained 12 weeks,and gradual withdrawal was conducted,and followed by follow-up for 3 months. The clinic data was observed,including the clinical efficacy,tinnitus disability scale(THI)score,visual analogue scale(VAS)score,tinnitus loudness(TI)and incidence of adverse reactions before and after treatment. RESULTS:The effective rate was 66.67%;after treat-ment,the scores of THI and VAS,and TI were significantly lower than before,with significant differences(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:The alprazolam by progressive dose increasing has obvious effica-cy in the treatment of chronic tinnitus,with good safety.关键词
阿普唑仑/慢性耳鸣/渐进式/加量治疗/疗效/安全性Key words
Alprazolam/Chronic tinnitus/Progressive/Dose increasing treatment/Efficacy/Safety分类
医药卫生引用本文复制引用
樊国强,宋谨,杜娟,赖海燕..阿普唑仑渐进式加量治疗慢性耳鸣的疗效与安全性观察Δ[J].中国药房,2015,(21):2899-2900,2901,3.基金项目
2011年盐田区第三批产业发展资料项目--阿普唑仑治疗耳鸣给药方案设计及疗效观察 （）
