中国药房Issue(21)：2904-2905,2906,3.DOI:10.6039/j.issn.1001-0408.2015.21.09
阿托伐他汀钙对代谢综合征患者颈动脉内中膜厚度及其他相关指标的影响Δ
Effect of Atorvastatin Calcium on the Carotid Intima-media Thickness and Related Indicators in Patients with Metabolic Syndrome
摘要
Abstract
OBJECTIVE:To investigate the effect of atorvastatin calcium on the carotid intima-media thickness(IMT)and other related indicators in patients with metabolic syndrome(MS). METHODS:The data of 1 444 patients with MS were retrospectively analyzed and randomly divided into observation group(874 cases)and control group(570 cases)by different medication. All patients were given healthy lifestyle,antihypertensive,hypoglycemia and lowering blood lipid guidance. On this basis,treatment group was orally given atorvastatin calcium 20 mg,once every evening. The follow-up was conducted for 3 years. The clinic data in 2 groups was compared,including body mass index(BMI),waist circumference(WC),systolic blood pressure(SBP),diastolic blood pressure (DBP),pulse pressure(PP),IMT,total cholesterol(TC),triglyceride(TG),low conspired lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),high-sensitivity C-reactive protein(hs-CRP),fasting plasma glucose(FPG)and incidence of adverse reactions before and after treatment. RESULTS:After treatment,compared with before and control group,the BMI、WC、SBP、DBP、PP、IMT、TC、TG、LDL-C、HDL-C、hs-CRP and FPG in observation group were significantly improved,only TG、LDL-C and HDL-C in control group were significantly improved,the differences were statistically significant(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Based on the conventional treatment,atorvastatin calcium can effectively improve the IMT and blood lipid,blood pressure and blood glucose of patients with MS,with good safety.关键词
代谢综合征/颈动脉内中膜厚度/阿托伐他汀钙Key words
Metabolic syndrome/Carotid intima-media thickness/Atorovastatin calcium分类
医药卫生引用本文复制引用
许绍忠,李冬青,王希柱,臧书梅,孙玉艳,高明,张宝霞..阿托伐他汀钙对代谢综合征患者颈动脉内中膜厚度及其他相关指标的影响Δ[J].中国药房,2015,(21):2904-2905,2906,3.基金项目
唐山市科学技术研究与发展计划增补项目 （）
