中国药房Issue(21)：2999-3000,2.DOI:10.6039/j.issn.1001-0408.2015.21.43
长春西汀原料药细菌内毒素检查法研究
Study on Bacterial Endotoxin Test of Vinpocetine Raw Material
周继春1
作者信息
- 1. 河南省食品药品检验所，郑州 450003
- 折叠
摘要
Abstract
OBJECTIVE:To establish a method for the bacterial endotoxin test of vinpocetine raw material. METHODS:Ac-cording to the bacterial endotoxin test in the Chinese Pharmacopoeia(2010 edition,Ⅱ)Appendix Ⅺ E,the samples with different batches were used for interference test and bacterial endotoxin test by tachypleus amebocyte lysate from 2 manufacturers. RE-SULTS:The vinpocetine solutions with high concentration have interference effect on the agglutination reaction of bacterial endotox-in and the interference can be eliminated by diluting. CONCLUSIONS:The non-interference concentration of vinpocetine solutions is 0.25 mg/ml. Bacterial endotoxin test can be used to control the quality.关键词
长春西汀原料药/细菌内毒素/鲎试剂/干扰试验Key words
Vinpocetine raw material/Bacterial endotoxin/Tachypleus amebocyte lysate/Interference test分类
医药卫生引用本文复制引用
周继春..长春西汀原料药细菌内毒素检查法研究[J].中国药房,2015,(21):2999-3000,2.
