中国医科大学学报Issue(5)：407-410,4.
阿托伐他汀对大鼠心肌缺血再灌注保护作用的实验研究
Protective Effects of Atorvastation on Myocardium Ischemia Reperfusion Injury in Rats
摘要
Abstract
Objective To investigate the protective effects of atorvastation on myocardium ischemia reperfusion injury in rats. Methods A total of 54 SD rats were randomized into three groups:atorvastatin group(n=18),ischemia reperfusion group(n=18),and sham-operated group(n=18);the rat model of myocardial ischemia-reperfusion was established,and 8 rats were sacrificed from atorvastatin group and ischemia reperfusion group for Evans blue and TTS staining. Myocardial infarct size of the16 rats were analyzed using image processing software. The level of malondialdehyde (MDA)were measured by thiobarbituric acid method(TBA);tumor necrosis factor-alpha(TNF-α)and myeloperoxidase(MPO)were determined by enzyme-linked immunoadsordent assay(ELISA). 14 days after the operation,the hemodynamic parameters and ventricular remodeling of remain-ing 30 rats were measured. Results Myocardial infarct size of atorvastatin group was lower than ischemia reperfusion group;compared with the sham-operated group,the level of MDA,TNF-αand MPO were increased in both ischemia reperfusion group and atorvastatin group,but rate of increase is lower in atorvastatin group than ischemia reperfusion group;the hemodynamic parameters and ventricular remodeling of rats were significantly im-proved,all the differences were all significant(P<0.05). Conclusion Atorvastatin can reduce the myocardial infarct size,improve the hemody-namic parameters and ventricular remodeling in rat myocardium ischemia-reperfusion injury.关键词
阿托伐他汀/心肌缺血/再灌注损伤Key words
atorvastatin/myocardial ischemia/reperfusion injury分类
医药卫生引用本文复制引用
杜萍,常栋,陈畅..阿托伐他汀对大鼠心肌缺血再灌注保护作用的实验研究[J].中国医科大学学报,2014,(5):407-410,4.基金项目
国家自然科学基金 （）
