摘要
Abstract
Objective To investigate the expression of DOG1,CD117,and Ki-67 in gastrointestinal stromal tumors and explore their relationship with the clinicopathological factors and risk rank of GISTs. Methods Immunohistochemical method was adopted to detected the expression of DOG1,CD117,and Ki67 in 66 cases of GIST. The risks in all cases were also ranked. The correlation between immunohistochemical indicators and clinicopathological factors and risk ranks of GISTs were analyzed. Results Among the 66 GISTs,the positive rates of DOG1 and CD117 were 93.94%and 65.15%. The positive rate of DOG1 in CD117 negative GISTs was 82.61%. had There were no significant difference among groups in gender,age,position,tumor size,tumor mitotic count in the expression of DOG1 and CD117 and risk rank(P>0.05). However,DOG1 was more sensitive than CD117(P<0.01). The number of cases with Ki67 proliferation indices<1%,1%-5%and>5%were 15,20,and 24,respectively. The positive rate of Ki67 was 89.39%. No significant difference was found in the expression of Ki67 among groups in gender,age,and position(P>0.05). Nevertheless,e Ki67 protein expression was positively correlated with the tumor size,tumor mitotic count and risk rank(P<0.01)(r=0.488, r=0.425,r=0.550). The positive rate of Ki67 was a little bit higher in CD117 positive GISTs than the these DOG1 positive cases,but there was no significant difference(P>0.05). Conclusion DOG1 has higher sensitivity than CD117 in GISTs. Ki67 protein,tumor size,and tumor mitotic count were risk indicators for GISTs and could be predictors for prognosis.关键词
胃肠道间质瘤/DOG1/CD117/Ki67增殖指数/危险度Key words
gastrointestinal stromal tumors/DOG1/CD117/Ki67/risk rank分类
医药卫生
