中国医科大学学报Issue(6)：485-488,4.
原发性高血压并左心室肥厚与基质金属蛋白酶及其组织抑制因子的关系
Relationship of Matrix Metalloproteinases and the Tissue Inhibitor with Left Ventricular Hypertrophy in Patients with Primary Hypertension
摘要
Abstract
Objective To investigate the relationship of matrix metalloproteinases(MMP⁃3 and MMP⁃9)and the tissue inhibitor TIMP⁃1 with left ventricular hypertrophy(LVH)in patients with primary hypertension. Methods Totally 140 patients with primary hypertension and 132 healthy controls were included. Matrix metalloproteinase⁃3(MMP⁃3),matrix metalloproteinase⁃9(MMP⁃9)and tissue inhibitor metalloproteinase⁃1 (TIMP⁃1)were measured. All subjects were taken echocardiography examination ,then left ventricular mass index(LVMI)was calculated. Re⁃sults MMP⁃3,MMP⁃9,TIMP⁃1(488.32±100.32 vs 314.59±99.78;340.56±43.21 vs 290.15±33.98;389.16±57.53 vs 243.45±62.31;P<0.001) and LVMI(113.7±9.9 vs 88.3±10.4,P<0.001)in patients with primary hypertension were significantly higher than those in controls. In a multiple stepwise regression analysis with LVMI as the variable,it was found that age,SBP,MMP⁃3,MMP⁃9 and TIMP⁃1 were main determinants for LVMI (r2=0.78,P<0.001). 3. Patients with primary hypertension were divided into two subgroups according to LVMI,i.e.,hypertension with LVH (group A)and hypertension without LVH(group B). SBP,MMP⁃3,MMP⁃9 and TIMP⁃1(178±31 vs 166±25;490.14±99.13 vs 405.56±53.12;340.56±43.21 vs 290.15±33.98;393.45±47.69 vs 301.58±39.57;P<0.05)of group A were significantly higher than those of group B. Conclusion MMP⁃3,MMP⁃9 and TIMP⁃1 are influencing factors for LVH in patients with primary hypertension.关键词
原发性高血压/基质金属蛋白酶3/基质金属蛋白酶9/金属蛋白酶组织抑制因1/左心室肥厚Key words
primary hypertension/matrix metalloproteinase-3/matrix metalloproteinase-9/tissue inhibitor metalloproteinase-1/left ventricular hypertrophy分类
医药卫生引用本文复制引用
吴宝刚,郝瑩,李乃静,白雪,周勇..原发性高血压并左心室肥厚与基质金属蛋白酶及其组织抑制因子的关系[J].中国医科大学学报,2015,(6):485-488,4.基金项目
国家自然科学基金 （）
