中国医科大学学报Issue(7)：606-609,613,5.
沉默信息调节因子2相关酶1在直肠癌中的表达及临床意义
Expression and Clinical Significance of Sir2-related Enzymes-1 in Colorectal Cancer
摘要
Abstract
Objective To investigate the expression and clinical significance of Sir2⁃related enzymes⁃1(SIRT1)in colorectal cancer. Methods The expression of SIRT1 was evaluated by immunohistochemistry in 86 selected cases of primary Colorectal cancer and 30 samples of normal rectum tissues besided carcinoma. The relationship of the expression and clinical pathological features were analyzed. Results The positive expression rate of SIRT1 in Colorectal cancer tissue was 88.4%,and significantly higher than in normal rectum tissue besided carcinoma(P<0.001). There were no correlation between the expression of SIRT1 and sex,age and tumor diameter,and significant positive correlation between the expression of SIRT1 and TNM stage (P<0.05),lymph node metastasis(P<0.05),infiltrating depth(P<0.05),and negagtive correlation between the expression of SIRT1 and tumor differentiation(P<0.05). Conclusion The positive expression rate of SIRT1 in colorectal cancer tissue was significantly higher than in normal rectum tissue besided carcinoma and intimate correlation with tumor differentiation,TNM stage,lymph node metastasis and Infiltrat⁃ing depth. Conclusion SIRT1 may be an important assistance gene to diagnose and judge prognosis,and may improve diagnostic rate and auxiliari⁃ly judge prognosis as a important Colorectal cancer marker.关键词
沉默信息调节因子2相关酶1/直肠癌/免疫组化Key words
Sir2-related enzymes-1/colorectal cancer/immunohistochemistry分类
医药卫生引用本文复制引用
齐晓莹,蒋中秀,刘洋,李宁,张晓晔..沉默信息调节因子2相关酶1在直肠癌中的表达及临床意义[J].中国医科大学学报,2015,(7):606-609,613,5.基金项目
辽宁省自然科学基金 （）
