中国药理学通报Issue(5)：688-691,4.DOI:10.3969/j.issn.1001-1978.2014.05.022
红景天苷对腹水型H22肝癌抑制作用及其机制的初步研究
Preliminary study on the inhibitory effect of salidroside on H22 ascites hepatoma
摘要
Abstract
Aim To investigate the inhibitory effect of salidroside on tumor growth in tumor-bearing mice and explore its possible mechanisms of anti-tumor action in vivo. Methods The tumor-bearing mice model was established, and the mice were randomly divided into five experimantal groups, including the salidroside low, medium and high doses groups, NS group and positive control matrine group. After continuous injec-tion of drug for eight days, the tumor growth and sur-vival time were measured, tumor growth inhibition rate and life extension rate, spleen index,the content of se-rum IL-2 and IL-12 were calculated. Results The general situation of the salidroside mice was better than the NS group and the positive control matrine group. Compared with NS group, the salidroside low,medium and high doses groups showed inhibitory effects on H22 solid tumor ( P<0. 01 ) with inhibition ratio 28. 9 %, 43. 3 % and 53. 5 %,and lengthened the survival time of mice ( P<0. 01 ) with the life extension rate 37. 54%,48. 96 % and 52. 85 % respectively. The spleen index and the content of serum IL-2 and IL-12 of the salidroside mice were significantly higher than NS group and matrine group. Conclusion Salidroside has marked inhibitory effects on tumor growth in vivo, its mechanism is probably related to improving the anti-tumor immune function.关键词
红景天苷/H22/肿瘤/生存时间/免疫/机制Key words
salidroside/H22/tumor/survival time/immunity/mechanism分类
医药卫生引用本文复制引用
何小喜,莫书荣..红景天苷对腹水型H22肝癌抑制作用及其机制的初步研究[J].中国药理学通报,2014,(5):688-691,4.基金项目
广西高校科学技术研究项目(No 2013YB050) （No 2013YB050）
