中国药理学通报Issue(6)：752-756,5.DOI:10.3969/j.issn.1001-1978.2014.06.004
催产素受体配体及其中枢和外周功能研究进展
Research progress of oxytocin receptor ligands and its role in central nerve system and peripheral organs
摘要
Abstract
Oxytocin ( OT ) is a cyclic neuropeptide containing nine amino acids residues, in addition to the traditional roles of uterine contraction and lactation, it also plays important roles in the central nervous system and other peripheral organs, such as improving schizophrenia, autism - related psychiatric and psy-chological symptoms. Oxytocin exhibits its physiological func-tions by binding to its receptor (oxytocin receptor,OTR). Cur- <br> rently researchers are manipulating OT system by developing new OTR ligand ( agonists and antagonists ) , hoping to prevent and treat OTR related diseases. This paper reviews the latest devel-opment of OTR agonists, antagonists and its physiological roles in central nerve system and peripheral organs.关键词
催产素/催产素受体/配体/激动剂/拮抗剂/中枢神经系统/外周器官Key words
oxytocin/oxytocin receptor/ligands/agonists/antag-onists/central nerve system/peripheral organs分类
医药卫生引用本文复制引用
孟雅婧,杨洋,刘莹,安输,徐天瑞..催产素受体配体及其中枢和外周功能研究进展[J].中国药理学通报,2014,(6):752-756,5.基金项目
云南省高端科技人才基金(No 2012HA008) （No 2012HA008）
云南省人培基金资助(No KKSY201226129) （No KKSY201226129）
