中国药理学通报Issue(8)：1041-1044,4.DOI:10.3969/j.issn.1001-1978.2014.08.002
丹参酮类抗肿瘤作用与机制研究进展
Research progress on the anti-cancer effect and mechanisms of the natural tanshinones
摘要
Abstract
Tanshinones are a large class of hydrophobic natural products isolated from traditional Chinese herb Salvia miltiorrhiza Bunge and related plants. Tanshinones include tanshinone ⅡA, cryptotanshinone, tanshinone I, dihydrotanshinone, and so on. Both the tanshinones and the salvianolic acids have been identi-fied as the characteristic and main active ingredients of Salvia miltiorrhiza Bunge with cardiovascular protective activities. Ac-cumulated data in recent years have revealed that tanshinones possess remarkable anti-cancer activities both in vivo and in vitro. In this review, we summarize the latest progress of the an-ti-cancer effect and the underlying mechanisms of tanshinones, particularly with emphasis on tanshinone ⅡA, which might pro-vide reference for the further research and development of these compounds.关键词
丹参酮ⅡA/隐丹参酮/丹参酮I/二氢丹参酮I/肿瘤/作用与机制/进展Key words
tanshinone ⅡA/cryptotanshinone/tanshinone I/dihydrotanshinone I/cancer/effect and mechanisms/progress分类
医药卫生引用本文复制引用
郝文慧,赵文文,陈修平..丹参酮类抗肿瘤作用与机制研究进展[J].中国药理学通报,2014,(8):1041-1044,4.基金项目
澳门科学技术发展基金( No 021/2012/A1) （ No 021/2012/A1）
澳门大学研究基金( No MRG007/CXP/2013/ICMS, MRG008/CXP/2013/ICMS) （ No MRG007/CXP/2013/ICMS, MRG008/CXP/2013/ICMS）
