中国药理学通报Issue(9)：1201-1204,1205,5.DOI:10.3969/j.issn.1001-1978.2014.09.005
新型益脑双联体防治阿尔采末病作用及机制研究进展
Research progress in characterizing multiple-target mechanisms of novel anti-Alzheimer's dimers
摘要
Abstract
Alzheimer's disease ( AD ) is a complex disease caused by environmental and genetic factors. Therefore, one-drug-multiple-target compounds represent the most promising pharmacological approaches to preventing and treating this dis-ease. We have previously designed and synthesized bis( n)-Cog-nitin, novel anti-Alzheimer's dimers derived from tacrine. Bis ( n)-Cognitin have been proven to act on multiple important AD targets, including acetylcholinesterase, β-secretase, N-methyl-D-aspartic acid receptor and neuronal nitric oxide synthase, con-currently. Moreover, Bis(n)-Cognitin could inhibit β-amyloid-induced neurotoxicity, decrease glutamate-induced excitotoxici-ty, reduce oxidative stress, improve learning and memory, and protect against neuronal apoptosis in various in vitro and in vivo models, suggesting that bis ( n )-Cognitin are potential anti-AD drug candidates.关键词
阿尔采末病/他克林双联体/多靶点/神经保护/分子机制/乙酰胆碱酯酶/β-淀粉样蛋白Key words
Alzheimer's disease/bis ( n )-Cognitin/multiple targets/neuroprotection/molecular mechanisms/acetylcholinest-erase/β-amyloid分类
医药卫生引用本文复制引用
苏玮,朱龙军,许大平,崔巍,张在军,胡胜全,麦成雄,韩怡凡..新型益脑双联体防治阿尔采末病作用及机制研究进展[J].中国药理学通报,2014,(9):1201-1204,1205,5.基金项目
国家自然科学基金资助项目( No 81202510) （ No 81202510）
香港政府研究基金( No PolyU5610/11M、PolyU5609/09M) （ No PolyU5610/11M、PolyU5609/09M）
香港理工大学研究基金( No G-U952、G-YM32、G-YZ15) （ No G-U952、G-YM32、G-YZ15）
香江学者资助项目(No 122870) （No 122870）
