中国药理学通报Issue(9)：1311-1314,1315,5.DOI:10.3969/j.issn.1001-1978.2014.09.027
两色金鸡菊醇提物对自发性高血压大鼠尿液的代谢组学研究
Effect of alcohol extract from Coreopsis tinctoria Nutt. on spontaneous hypertension rats by metabolomic methods
摘要
Abstract
Aim To investigate the effects of the alco-hol extract from Coreopsis tinctoria Nutt. on urinary metabolomics of spontaneous hypertension rats ( SHR) . Methods SHR were fed with normal diet for 1 week and then, they were randomly divided into six groups:untreated control, the high, middle, low dos-age group of the alcohol extract(3.2 g·kg-1 ,1.6 g· kg-1,0.8 g·kg-1) , captopril group(4 mg·kg-1) and Duzhong tablet group(187.5 mg·kg-1). The u-rine of normal rats and SHR hypertension model rats was collected on 1,2,3,4 weeks. The metabolic pro-files were analyzed using 1 H-NMR. PLS-DA methods were used to discriminate the difference and the bio-markers. Results Compared with model group, the blood pressure of all groups was significantly lowered after 4 weeks ( P <0.01 ) . The alcohol extract from Coreopsis tinctoria Nutt. could significantIy reduce blood pressure, and the urinary metabolic profiles trea-ted with Coreopsis tinctoria Nutt. were changed signifi-cantly such as IIL,creatine,β-glucose,etc. Conclusion The alcohol extract from Coreopsis tinctoria Nutt. could significantIy reduce blood pressure and change the urinary metabolomics profiles of SHR rats.关键词
两色金鸡菊/高血压/大鼠/尿液/代谢组学/核磁共振Key words
Coreopsis tinctoria Nutt./hypertension/rat/urine/metabolomics/NMR分类
医药卫生引用本文复制引用
卢伟,马晓丽,兰怡,李琳琳,王烨,靳春丽,毛新民..两色金鸡菊醇提物对自发性高血压大鼠尿液的代谢组学研究[J].中国药理学通报,2014,(9):1311-1314,1315,5.基金项目
新疆维吾尔自治区科技支撑项目(No 201333119) （No 201333119）
