中国药理学通报Issue(10)：1353-1356,4.DOI:10.3969/j.issn.1001-1978.2014.10.006
血管紧张素Ⅱ及其受体与类风湿关节炎
Angiotensin Ⅱ and receptors in rheumatoid arthritis
摘要
Abstract
Angiotensin Ⅱ and type 1 receptor ( AT1R) are ab-solutely therapeutic targets in the hypertension and cardiovascular disease, and angiotensin Ⅱ gets involved in monocytes chemo-taxis and migration, T lymphocytes activation and proliferation, Th1 and Th17 immune function, and synoviocytes apoptosis inhi-bition in patients with rheumatoid arthritis ( RA) through binding to AT1R in the autocrine and/or paracarine manner. Drugs that limit angiotensin Ⅱ production by angiotensin converting enzyme inhibitors ( ACEIs) or blockade of angiotensin Ⅱ-AT1R action by AT1R blocker ameliorate immune and inflammation responses in RA patients. Additionally, angiotensin Ⅱ type 2 receptor (AT2R) expression increases in RA and experimental model, and activation of AT2R exerts a therapeutic effect on adjuvant-in-duced arthritis. AngiotensinⅡand its receptors in RA and auto-immune diseases are retrospectively reviewed in this paper.关键词
血管紧张素Ⅱ/1型受体/2型受体/类风湿关节炎/炎症免疫/1型受体阻断剂Key words
angiotensin Ⅱ/type 1 receptor/type 2 receptor/rheumatoid arthritis/immune and inflammation/type receptor blocker分类
医药卫生引用本文复制引用
王迪,胡姗姗,魏伟..血管紧张素Ⅱ及其受体与类风湿关节炎[J].中国药理学通报,2014,(10):1353-1356,4.基金项目
国家自然科学基金重点项目( No 81330081) （ No 81330081）
国家自然科学基金面上项目( No 81173075) （ No 81173075）
2012年高校博士学科点专项科研基金(博导类)( No 20123420110003) （博导类）
安徽省2013科技攻关计划项目(No 1301042098) （No 1301042098）
