中国药理学通报Issue(1)：7-10,4.DOI:10.3969/j.issn.1001-1978.2015.01.002
α-突触核蛋白与Cu2+相互作用的研究进展
Research progress of the interaction of α-synuclein proteins and Cu2+ Ion
摘要
Abstract
Parkinson’ s disease ( PD) is a chronic degenerative disease of the central nervous system. The pathological hallmarks of PD are the loss of the nigrostriatal dopaminergic neurons and the presence of intraneuronal proteinacious cytoplasmic inclu-sions, termed“Lewy Bodies” (LBs). Its main component is the abnormal aggregated α-synuclein. Multiple factors have have been shown to affect α-synuclein aggregation. Metal ions com-bine with α-synuclein can lead to protein conformation changes that inducing protein aggregation. In recent years, the study found that Cu2+ could bind specifically to the protein and trigger its aggregation under conditions. It might be relevant for the de-velopment of PD. This present review attempts to look at the evi-dence for coordination, affinity and the physiology function of Cu2+ binding to α-synuclein.关键词
α-synuclein/异常聚集/Cu2+/相互作用/结合位点/亲和力/毒性形式Key words
α-synuclein/abnormal aggregation/Cu2+/interac-tion/binding site/affinity/toxicity分类
医药卫生引用本文复制引用
闫文芬,陈乃宏,苑玉和..α-突触核蛋白与Cu2+相互作用的研究进展[J].中国药理学通报,2015,(1):7-10,4.基金项目
国家自然科学基金资助项目( No 81274122,81102831,81073078,81373997,81373510) （ No 81274122,81102831,81073078,81373997,81373510）
教育部博士点基金重点项目(No 2012110613000) （No 2012110613000）
天然产物生物活性物质结构及功能的研究( No IRT1007) （ No IRT1007）
北京市自然科学基金重点项目(No 731013) （No 731013）
