中国药理学通报Issue(1)：11-14,4.DOI:10.3969/j.issn.1001-1978.2015.01.003
雷帕霉素诱导细胞自噬在衰老相关疾病中的作用
Effects of rapamycin induced cellular autophagy in aging-related diseases
摘要
Abstract
Mammalian target of rapamycin( mTOR) is a key reg-ulator of aging and aging-related diseases. Rapamycin ( RAPA) induces and promotes the process of cell autophagy through in-hibiting mTOR pathway. Autophagy exerts a crucial role in main-taining the cellular meostasis, which provides essential materials for cell reconstruction, regeneration and repair via degradating the redundant, damaged, or senescent proteins and organelles. Hutchinson Gilford progeria syndrome ( HGPS ) patients are al-ways accompanied with abnormally accumulated progerin in cells. Similar to HGPS, abnormal protein accumulation is the common pathological feature of neurodegenerative diseases, in-cluding Huntington′s disease, Parkinson′s disease, Alzheimer′s disease and so on. Degradation of these abnormal proteins pre-dominantly depends on cell autophagy. Thus, rapamycin is a po-tential anti-aging drug for HGPS and aging-related diseases thera-py. This view focuses on the effects of rapamycin on cell autoph-agy and clinical application in HGPS and neurodegenerative dis-eases.关键词
雷帕霉素/雷帕霉素靶蛋白/自噬/早老症/早老蛋白/神经退行性疾病Key words
rapamycin/TOR/autophagy/HGPS/progerin/neurodegenerative diseases分类
医药卫生引用本文复制引用
吴伯艳,刘新光,陈维春..雷帕霉素诱导细胞自噬在衰老相关疾病中的作用[J].中国药理学通报,2015,(1):11-14,4.基金项目
国家自然科学基金资助项目( No 30900739,81170327,31201036) （ No 30900739,81170327,31201036）
广东省自然科学基金资助项目( No 9152402301000007) （ No 9152402301000007）
东莞市科技计划( No 2008108101062,2012108102022) （ No 2008108101062,2012108102022）
