中国药理学通报Issue(4)：458-460,461,4.DOI:10.3969/j.issn.1001-1978.2015.04.004
血管紧张素Ⅱ调控骨代谢的研究进展
Research progress on regulation of angiotensin Ⅱ on bone metabolism
摘要
Abstract
The renin-angiotensin system exists locally in bone tissue.The RAS components and the active peptide angiotensinⅡ (Ang Ⅱ)within RAS are directly involved in the pathophysi-ological process of regulating bone metabolism.Ang Ⅱ exerts the effects via its receptors expressed in osteoblasts and osteoclasts. This paper reviewed the pathways of classical RAS,explained the tissue RAS-induced tissue injuries,and especially elaborated the regulation of RAS active peptide Ang Ⅱ on target genes and in-tracellular signaling pathways in osteoblasts,the action of Ang Ⅱon osteoclastic function via acting on osteoblasts,and the inter-action of Ang Ⅱ receptors involved in the modulation on bone metabolism.关键词
肾素 -血管紧张素系统/血管紧张素Ⅱ/成骨细胞/破骨细胞/骨质疏松症/受体Key words
renin-angiotensin system/angiotensin Ⅱ/osteo-blasts/osteoclasts/osteoporosis/receptor分类
医药卫生引用本文复制引用
刘金鑫,张方怡,张岩..血管紧张素Ⅱ调控骨代谢的研究进展[J].中国药理学通报,2015,(4):458-460,461,4.基金项目
国家自然科学基金资助项目 （）
