中国药理学通报Issue(7)：889-894,6.DOI:10.3969/j.issn.1001-1978.2015.07.001
干细胞治疗阿尔茨海默病的研究进展及挑战
Advance and challenges in stem cell therapy for Alzheimer’ s disease
摘要
Abstract
Alzheimer’ s disease ( AD) , the most prevalent type of neurodegenerative disease, characterized by extracellular β-amyloid ( Aβ) plaque deposition, intracellular neurofibrillary tangles, and the loss of diverse neurons. Neuron loss might be the main cause that induces irreversible decline of cognitive function in AD patients. At present, AD therapy only relieves symptoms instead of fundamentally affecting the major pathologi-cal characteristics of the disease. Recently, rapid advances in neurogenesis and stem-cell biology have provided a new and pro-spective potential for AD treatment. Stem-cell types in the treat-ment of neurodegenerative diseases include neural stem cells ( NSCs ) , embryonic stem cells ( ESCs ) , mesenchymal stem cells ( MSCs ) , and induced pluripotent stem cells ( iPSCs ) . Stem cell therapy shows anti-AD function by replacing the dam-aged and lost neurons, rebuilding the cellular loop, inhibiting amyloidogenesis, promoting neurotrophic factor release, and reg-ulating immune reaction. This review highlights the recent pro-gress, mechanisms, and preclinical evidence of exogenous trans-planted stem cell, and addresses the current major challenges of stem cell transplantation in clinic. In addition, this review also summarizes the research status of compound promoting endoge-nous neurogenesis in brief.关键词
阿尔茨海默病/神经再生/神经干细胞/胚胎干细胞/骨髓间充质干细胞/诱导性多功能干细胞Key words
Alzheimer ’ s disease/neurogenesis/neural stem cells/embryonic stem cells/mesenchymal stem cells/induced pluripotent stem cells分类
医药卫生引用本文复制引用
张喻,肇玉明,王晓良,彭英..干细胞治疗阿尔茨海默病的研究进展及挑战[J].中国药理学通报,2015,(7):889-894,6.基金项目
国家自然科学基金资助项目( No 81473200) （ No 81473200）
教育部新世纪优秀人才支持计划( No NECT-10-0961) （ No NECT-10-0961）
国家科技部“重大新药创制”科技重大专项( No 2012ZX09301002-004) （ No 2012ZX09301002-004）
