中国药理学通报Issue(7)：915-918,919,5.DOI:10.3969/j.issn.1001-1978.2015.07.006
MTHFR-C677 T基因多态性-抑郁症治疗的新思路
MTHFR 677 C/T polymorphism-new ideas about depressive disorder treatment
摘要
Abstract
It has been confirmed that genetic factor plays an im-portant role in the pathogenesis of depression. MTHFR is one of the key enzymes in folate and homocysteine ( Hcy ) metabolism which participates in Alzheimer’ s disease, depression and other mental illnesses. MTHFR-677C/T polymorphism causes the de-crease of enzyme activity and heat resistance, which will lead to lower folate and elevated plasmal Hcy concentration. All of these results put together will cause the central neuronal damage and microvascular damage and affect the synthesis of central neuro-transmitter and methylation of biogenic amines and phospholipids in the central nervous system, which will eventually induce vari-ous mental illnesses like depression, etc. This article reviews the research advancement in the relationship between MTHFR-677C/T polymorphism and depression in recent years on the basis of MTHFR gene mutation and function, lack of folic acid, elevated plasma homocysteine levels and the MTHFR-C677T polymor-phism. Based on which we hope to bring new ideas about treat-ment of depression.关键词
遗传因素/MTHFR-C677T基因突变/Hcy/叶酸/神经递质/抑郁症Key words
genetic factor/MTHFR-677C/T polymorphism/Hcy/folate/neurotransmitter/depression分类
医药卫生引用本文复制引用
刘婉婉,董宪喆,刘屏..MTHFR-C677 T基因多态性-抑郁症治疗的新思路[J].中国药理学通报,2015,(7):915-918,919,5.基金项目
国家自然科学基金资助项目(No 81173430) （No 81173430）
