摘要
Abstract
Oxycodone,an opioid receptor agonist,is one of potent narcotic analgesics. Despite its potent analgesic effect,the tolerant and dependent liability of oxycodone as well as its inhibition on gas-trointestinal motility strongly restricts its clinical application. Since the end of the last century,antipyretic, opioid receptor agonist,opioid receptor antagonist and dopamine receptor antagonist have been used to in combination with oxycodone at different ratios as complex prescriptions,the aim of which is to enhance the effect of oxycodone,decrease the dosage of oxycodone,and prevent the adverse effect and the tendency for misuse. Here we reviewed the development of oxycodone compositions in the recent years,hoping to provide more data for its potential clinical application.关键词
羟考酮/镇痛药,非麻醉/受体拮抗剂,阿片/受体激动剂,阿片/罗通定Key words
oxycodone/antipyretic,non-narcotic/receptor antagonist,opioid/receptor agonist, opioid/rotundine分类
医药卫生
