中国药理学与毒理学杂志Issue(5)：774-778,5.DOI:10.3867/j.issn.1000-3002.2014.05.014
Zn（N2O2）型锌配合物及 L-茶氨酸锌与糖尿病关系的研究进展
Progress in reIations of zinc compounds with Zn(N2O2)coordination mode and L-theanine-zinc with diabetes meIIitus
万红贵 1彭银成 1黄志旭 1严湘驹2
作者信息
- 1. 南京工业大学生物与制药工程学院，江苏 南京 211816
- 2. 无锡凯夫制药有限公司，江苏 无锡 214091
- 折叠
摘要
Abstract
Zinc and its compounds with insulin-like effects have been found to own such properties as strong bio-compatibility,good stability and remarkable hypoglycemic effect. Since the discovery of their insulin-like function,zinc compounds and their anti-diabetic effects have been a geobal focus of research. Zinc ion is involved in physiological and biochemical processes in vivo,such as in carbohy-drate and lipid metabolism. The mechanism of zinc and zinc complexes in anti-diabetic activity are sum-marized in this article,including direct participation in insulin synthesis,antioxidation,involvement in the regulation of tyrosine protein phosphatase,and improving immunity. Zinc complexes with Zn(N2 O2 )have remarkable insulin-like effects. Particularly,the L-theanine-zinc compound,which is a class of zinc com-plexes with natural ligands,has also been found to show significant hypoglycemic effect in an in vivo experiment on KK-Ay mice,have stable chemical properties,be absorbed fast in vivoand be non-toxic with oral administration during model animal experiments. This paper reviews the progress in research on relationships between zinc and its complexes and the anti-diabetic effect.关键词
L-茶氨酸/类胰岛素活性/糖尿病/锌配合物Key words
L-theanine/insulinomimetic activity/diabetes mellitus/zinc compound分类
医药卫生引用本文复制引用
万红贵,彭银成,黄志旭,严湘驹..Zn（N2O2）型锌配合物及 L-茶氨酸锌与糖尿病关系的研究进展[J].中国药理学与毒理学杂志,2014,(5):774-778,5.
