中国药理学与毒理学杂志Issue(5)：794-800,7.DOI:10.3867/j.issn.1000-3002.2014.05.018
量子点的神经毒性效应研究进展
Research advance in neurotoxicity of quantum dots
摘要
Abstract
As quantum dots( QDs),an advanced porduct of nanotechnology,have been widely used in bio-medicine due to their unique photoelectric properties. QD safety evaluation has become a hot area of research. So far,some researchers have expressed concern about the neurotoxic potential of QDs because the central nervous system was confirmed to be one of the target organs. Several studies found that QDs could enter the central nervous system by crossing the blood brain barrier and following neural pathways and produce some neurotoxic effects,such as damaging the structure and function of neural cells and impairing synaptic plasticity. The potential toxicity mechanisms could include oxidative stress,inflammation and change of ion channels.关键词
量子点/中枢神经系统/神经毒性效应/毒性机制Key words
quantum dots/central nervous system/neurotoxic effects/toxicity mechanism分类
医药卫生引用本文复制引用
吴添舒,唐萌..量子点的神经毒性效应研究进展[J].中国药理学与毒理学杂志,2014,(5):794-800,7.基金项目
国家自然科学基金（30671782）；国家自然科学基金（30972504）；国家自然科学基金（81172697）；国家自然科学基金（81302461）；国家重大科学研究计划（2011CB933404）；江苏省基础研究计划（BK2011606）@@@@ The project supported by National Natural Science Foundation of China（30671782）；National Natural Science Foundation of China（30972504）；National Natural Science Foundation of China（81172697）；National Natural Science Foundation of China （81302461）； National lmportant Project on Scientific Research of China （2011CB933404）；and Natural Science Foundation of Jiangsu Province （）
