中国药理学与毒理学杂志Issue(5)：806-812,7.DOI:10.3867/j.issn.1000-3002.2014.05.020
肝细胞药物转运体研究进展
Progress in drug transporters in hepatocytes
摘要
Abstract
Hepatic drug transporters(HDTs),including uptake transporters and efflux transporters, play an important role in drug distribution and elimination in the liver. The influx HDTs include organic anion transporters,organic cation transporters,organic anion transporter polypeptides and Na+-tauro-cholate cotransporting polypeptide. The efflux HDTs include multidrug resistance proteins,multidrug resistance-associated proteins,breast cancer resistance protein and bile salt export pumps. Major research methods involve gene knock-out animals,isolated perfused livers,liver slices,primary hepato-cytes and transfection cells. They have been used in study of drug distribution,drug-drug interaction and drug toxicity.关键词
肝细胞/药物/转运体Key words
hepatocytes/drug/transporters分类
医药卫生引用本文复制引用
朱蓉,马越鸣..肝细胞药物转运体研究进展[J].中国药理学与毒理学杂志,2014,(5):806-812,7.基金项目
国家自然科学基金（81273658）；高等学校博士学科点专项科研基金（20113107110005）；“085”一流学科建设科技创新支撑计划引导创新计划（085ZY1205）@@@@ The project supported by National Natural Science Foundation of China（81273658）；Research Fund for Doctoral Program of Higher Education of China（20113107110005）；and ″085″ Science and Technology lnnovation Support Program for Construction of the First-class Subject of ShanghaiGuiding lnnovation Plan （）
