中国药理学与毒理学杂志Issue(2)：260-264,5.DOI:10.3867/j.issn.1000-3002.2015.02.012
促性腺激素释放激素在雌二醇诱导的大鼠青春期启动提前中的作用
Role of gonadotropin-releasing hormone on advancing rat puberty onset induced by estradiol
摘要
Abstract
OBJECTIVE To investigate the role of gonadotropin-releasing hormone (GnRH) in es-tradiol(E2 ) induced advance of puberty onset in rats. METHODS Postnatal day 18 SD rats were given a daily intragastric administration of corn oil or E2(50 μg.kg-1 ) for consecutive 5 d. The day of vaginal opening (VO), pathological changes in ovary and protein expression levels of GnRH, G protein-coupled receptor 54 ( GPR54) and phospholipase C ( PLC) in hypothalamus were observed. RESULTS As compared to corn oil controll group, VO was advanced by about 12.2 d, corpus luteum was observed in the ovary section, and the protein expression levels of GnRH,GPR54 and PLC in hypothalamus were significantly increased by 47%, 55% and 56% in E2 group, respectively. CONCLUSION E2 induced onset of puberty advance may be closely related to regulation of the expression of GnRH, GPR54 and PLC in hypothalamus.关键词
雌二醇/青春, 早熟/促性腺激素释放激素Key words
estradiol/puberty/precocious/gonadotropin-releasing hormone分类
医药卫生引用本文复制引用
华辰凤,王以美,彭双清,杨嵘,刘羽欣,黄丽娜,张丽,张添光,田冬冬,赵君,赵增明..促性腺激素释放激素在雌二醇诱导的大鼠青春期启动提前中的作用[J].中国药理学与毒理学杂志,2015,(2):260-264,5.基金项目
国家自然科学基金(81172699)@@@@The project supported by National Natural Science Foundation of China (81172699) （81172699）
