中国药理学与毒理学杂志Issue(2)：317-322,6.DOI:10.3867/j.issn.1000-3002.2015.01.021
白细胞介素36及其在炎症性疾病中的作用
Advance in interleukin-36 and its role in inflammatory diseases
摘要
Abstract
Cytokines interleukin-36 ( lL-36) has 4 members: lL-36α, lL-36β, lL-36γ and lL-36 receptor agonists ( lL-36Ra). The signal of lL-36Ra, lL-36α, lL-36β and lL-36γ ( formerly lL-1F5, lL-1F6, lL-1F8, and lL-1F9) passes through the lL-1 receptor-related protein 2 and lL-1 receptor-acces-sory protein. lL-36Ra is a receptor antagonist that blocks the activation of lL-36 receptor signaling. lL-36 plays a significant role in the pathogenesis of several inflammatory diseases. This review introduces the biological characteristics, receptor and signal pathway, biological activity of lL-36 cytokines and their roles in the pathogenesis of a wide variety of inflammatory diseases.关键词
白细胞介素36/受体/拮抗剂/炎症Key words
interleukin-36/receptor/antagonist/inflammation分类
生物科学引用本文复制引用
彭笑,顾嘉杰,顾贤波,王凯,袁仙丽,李明才..白细胞介素36及其在炎症性疾病中的作用[J].中国药理学与毒理学杂志,2015,(2):317-322,6.基金项目
国家自然科学基金(81370166)浙江省自然科学基金项目(LY13H090014)宁波市科技创新团队项目(2011B82014)宁波市科技计划项目(2013C50054)宁波市重点学科项目(XKL11D2112)宁波市重点学科项目(XKL11D2113)宁波大学大学生科技创新计划项目@@@@The project supported by National Natural Science Foundation of China (81370166) Natural Science Foundation of Zhejiang Province ( LY13H090014) Scientific lnnovation Team Project of Ningbo City (2011B82014) Key Disciplines in Ningbo City ( XKL11D2112) Key Disciplines in Ningbo City ( XKL11D2113) and Student Research and lnnovation Program of Ningbo University （81370166）
