中国药理学与毒理学杂志Issue(2)：323-327,5.DOI:10.3867/j.issn.1000-3002.2015.01.022
NF-κB 在细胞凋亡中调节作用的研究进展
Advances in roles of NF-κB in regulating pathways of apoptosis
摘要
Abstract
Apoptosis is a process of programmed cell death that is controlled by genes. Normally, there are three regulation pathways involved in the process of apoptosis, including the signaling of intracel-lular mitochondria, endoplasmic reticula and extracellular death receptors. Recent studies showed that NF-κB is a key regulator in the process of apoptosis. NF-κB plays a promotional and a inhibitory role as well in the regulation of apoptosis, closely related to the the inhibitor of apoptosis proteins family, the B cell lymphoma/ lewkmia-2 family, tumor necrosis factor receptor associated factors, c-Jun N-terminal kinase, tumor necrosis factor related apoptosis inducing ligand and Fas-associated death domain protein-like interleukin-1β. Thus, investigation of the mechanism regarding NF-κB in apoptosis regulation is of great importance for apoptosis-related drug development. The paper reviews the recent research progress in the function of NF-κB in apoptosis pathway regulation.关键词
NF-κB/细胞凋亡Key words
NF-κB/apoptosis分类
生物科学引用本文复制引用
任改艳,孙阿宁,张晶晶,邓超,王峥涛,窦薇..NF-κB 在细胞凋亡中调节作用的研究进展[J].中国药理学与毒理学杂志,2015,(2):323-327,5.基金项目
国家自然科学基金(81273572)上海市教委科研创新项目(13YZ043)上海市自然科学基金(12ZR1431400)@@@@The project supported by National Natural Science Foundation of China (81273572) Shanghai Municipal Education Commission of Scientific Research lnnovation Project (13YZ043) and Shanghai Natural Science Foundation (12ZR1431400) （81273572）
