摘要
Abstract
Objective To investigate the effect of dexmedetomidine hydrochloride on inflammatory and oxidative stress responses during one lung ventilation.Methods 50 patients undergoing radical resection of esophageal cancer patients from 2013 September to 2014 September in our hospital patients,randomly divided into observation group and control group,each of 25 cases.The patients in study group after tracheal intubation,10 min in 1 g/kg intravenous infusion of dexmedetomidine hydrochloride,10 min after 0.5 g/(kg·H)continuous infusion is chest;patients in control group were treated with intravenous injection of equal volume of 0.9%Sodium Chloride Injection.Begin immediately to one lung ventilation(T0),60 min after one lung ventilation(T1)and the end of operation(T2)col ected venous blood,tumor necrosis factor alpha detection of two groups of patients with time points(TNF-a),interleukin 6(IL-6),serum malondialdehyde(MDA)and super oxide dismutase(SOD)concentration or level.Results Two groups of patients with T2 TNF-a,IL-6,MDA concentrations were significantly higher than the T0,the SOD activity in serum is lower than T0,the difference was statistical y significant(P<0.05);patients in the observation group T2 TNF-a,IL-6,MDA concentrations were significantly lower than the control group,the serum SOD activity is higher than that of the control group,the differences were there statistical significance(P<0.05).Conclusion Dexmedetomidine hydrochloride may inhibit the inflammatory response in lung tissue during one lung ventilation,reduce the degree of oxidative stress,and then play the lung protective effect.关键词
单肺通气/再灌注损伤/盐酸右美托咪定/肺损伤Key words
Single lung ventilation/Reperfusion injury/Dexmedetomidine hydrochloride/Lung injury分类
医药卫生
