摘要
Abstract
Objective To explore the expression of CD44v6 protein and CD3+ T cels and their prognostic value in esophageal squamous cel carcinoma.Methods Immunohistochemical method(SP)detection of CD44v6,CD3+ T cells expressing esophageal squamous cell carcinoma in 60 cases,and another 30 cases selected normal tissues adjacent to cancer as control,analyze its relationship with clinicopathological parameters.Results CD44v6 protein in esophageal cancer and adjacent normal tissue expression rate was 53.3%,16.7%,respectively,the difference was statisticaly significant(P<0.05);CD3+ T lymphocytes in esophageal cancer and adjacent normal tissue expression rate respectively 56.7%,80.0%,the difference was statisticaly significant(P<0.05);CD44v6 protein expression and CD3+ T lymphocytes were associated with low expression in esophageal squamous cell invasion,lymph node metastasis was positively correlated(P<0.05)However,the degree of differentiation, independent of lesion length(P>0.05); esophageal cancer in CD3+ T lymphocytes and CD44V6 protein expression showed a significant negative correlation(r=-0.481,P<0.01).Conclusion CD44v6 protein expression and low expression of CD3+ T lymphocytes in the development of esophageal squamous cel carcinoma occurs in closely related to invasion and metastasis.关键词
食管肿瘤/CD44v6蛋白/CD3+T淋巴细胞/免疫组织化学法/表达/预后Key words
Esophageal neoplasm/CD44v6/CD3+T cels/Immunohistochemistry/Expression/Prognosis分类
医药卫生
