中国药物评价Issue(4)：202-204,3.
阿司匹林与两性霉素B对白色念珠菌生物膜的体外联合作用研究
Study on the Effects of Aspirin Combined with Amphotericin B Against Candida Albicans Biofilms in Vitro
方甜甜 1宋沧桑 1李兴德 1田静1
作者信息
- 1. 昆明市第一人民医院药学部，云南昆明650034
- 折叠
摘要
Abstract
Objective:To study the effects of Amphotericin B combined with Aspirin on candida albicans biofilms in vitro.Methods:In vitro, a 96-well polymethylmethacrylate strips as the carrier established model of biofilm.Biofilm was identified by Silver nitrate stai-ning and was counted by crystal violet staining.Results:The result show that Amphotericin B (125 μg· mL-1 ) combined with aspirin (200 μg· mL-1) can significantly reduce the candida albicans biofilms compared with Amphotericin B (125 μg· mL-1) (P<0.05).Conclusion:The aspirin at pharmacological concentration (200 μg· mL-1 ) can significantly enhance the inhibition of Amphotericin B (125 μg· mL-1 ) on candida albicans biofilms in vitro.关键词
生物被膜/白色念珠菌/阿司匹林/两性霉素B/体外Key words
Biofilm/Candida albicans/Aspirin/Amphotericin B/Vitro分类
医药卫生引用本文复制引用
方甜甜,宋沧桑,李兴德,田静..阿司匹林与两性霉素B对白色念珠菌生物膜的体外联合作用研究[J].中国药物评价,2014,(4):202-204,3.
