摘要
Abstract
Objective:To study the efficacy and side effect of Paroxetine in the treatment of somatization disorder.Methods:13 com-parative studies of Paroxetine and other antidepressants in the treatment of somatization disorder were analyzed by meta -ananlysis.Re-sults:We included 13 studies with 723 patients.Four treatment period subgroups were created:2, 4, 6 and 8 weeks.In the 2-week sub-group, paroxetine was more efficacious than controlled group [MD=-2.10,95%CI(-3.52,-0.67),P=0.004].In the 4-week sub-group, paroxetine was more efficacious than controlled group [MD=-1.36,95%CI(-2.38,-0.33),P=0.009].In the 6-week sub-group, two drugs displayed comparative efficacy [ MD=-0.76 ,95%CI ( -1.87 ,-0.35 ) , P=0.18 ].In the 8-week subgroup , two drugs displayed comparative efficacy [MD=-0.50,95%CI( -1.32,-0.32),P=0.23].There were no significant differences in safety [ MD=-1.35 ,95%CI ( -6.77 ,-4.08 ].Conclusion: Paroxetine had a similar treatment effect and side effect to other con-trolled antidepressants.But Paroxetine had a earlier effect.It can improve the symptoms of somatoform disorder patients earlier.关键词
帕罗西汀/躯体形式障碍/Meta分析Key words
Paroxetine/Somatization disorder/Meta-ananlysis分类
医药卫生
