中国药物评价Issue(5)：284-288,5.
细菌溶解产物防治小儿反复呼吸道感染的 Meta 分析
Effects of Bacterial Lysates in Patients with Recurrent Respiratory Tract Infections：A Meta-analysis
马骏捷 1刘国恩 1姚瑶 1徐菲 1吕娜2
作者信息
- 1. 北京大学中国卫生经济研究中心，北京 100871
- 2. 优时比制药有限公司，北京 100020
- 折叠
摘要
Abstract
Objective:The use of bacterial lysates as an immune-modulator to boost immunological response in patients with recurrent respiratory tract infections (RRTI)and its effects on the attack frequency of respiratory infection have been widely debated.We aimed to conduct our Meta-analysis on the effect of bacterial lysates plus routine care versus routine care only on the attack frequency of respiratory infection in patients with RRTI.Methods: We performed a systematic review of articles published from January 1,2000 to November 10, 2013.We included all randomized trials that compared outcomes between patients with RRTI receiving bacterial lysates plus routine care with those receiving routine care only.Eligible studies, determined by consensus with predefined criteria,were reviewed and data were ex-tracted onto a standard form.We combined data to assess the primary outcome of attack frequency of respiratory infection using the DerSi-monian and Laird random effects model.Results: Our search identified 128 reports,of which 19 studies met our inclusion criteria and were included in our Meta-analysis.Analysis of the 19 randomized trials(959 patients) that reported an outcome on the attack frequency of respiratory infection showed that patients assigned to bacterial lysates plus routine care had a 2.963 reduction in respiratory tract infections compared to those assigned to routine care only.Conclusion: Bacterial lysates are associated with a decreased risk of respiratory tract in-fections in patients with RRTI.关键词
细菌溶解产物/小儿反复呼吸道感染/Meta 分析Key words
Bacterial lysates/Recurrent respiratory tract infection/Meta-analysis分类
医药卫生引用本文复制引用
马骏捷,刘国恩,姚瑶,徐菲,吕娜..细菌溶解产物防治小儿反复呼吸道感染的 Meta 分析[J].中国药物评价,2014,(5):284-288,5.
