中国药物评价Issue(1)：45-49,5.
10种中药注射剂联合长春瑞滨+顺铂化疗方案治疗非小细胞肺癌的网状Meta分析
Network Meta-analysis of 10 Chinese Herb Injections Combined with Vinorelbine and Cisplatin for Non Small Cell Lung Cancer
摘要
Abstract
Objective:To assess the clinical effects and safety of Chinese herb injection(CHI) combined vinorelbine and cisplatin ( NP) for non small cell lung cancer ( NSCLC ) based on the same comparison.Methods: The relative randomized controlled trials ( RCTs) of CHIs were searched from Science Citation Index Expanded ( SCI-EXPANDED) , EMBASE, PubMed,Cochrane Library, Can-cerLit, Chinese Knowledge Infrastructure,Chinese Scientific Journals Fulltext Database( VIP-CSJFD) ,Chinese Biomedical Literature Da-tabase( CBM) ,Wan-Fang Database( WANFANG) ,Chinese Science Citation Database( CSCD) and Traditional Chinese Medical Database System.The related references and website were also traced.The RCTs were screened according to the predefined inclusion and exclusion criteria,the related items were used to assess the quality of RCTs, data were analyzed by WinBugs software.Results:167 RCTs and 10 CHIs were finally included.The results of network Meta-analysis showed that, based on the NP intervention, there were significant differ-ence between only huachansu injection or yadanzyouru injection or aidi injection respectively and delisheng injection in quality of life. There were significant difference between only delisheng injection and yadanziyouru injection, huachansu injection or yadanziyouru injec-tion respectively and compound matrine injection or kanglaite injection or aidi injection, kang′ai injection and compound matrine injection or kanglaite injection or aidi injection in nausea and vomiting.There was no difference between 10 CHIs in efficacy.Conclusion:Based on the results of network Meta-analysis,delisheng injection,shengqifuzhe injection and yadanziyouru injection were more than other 7 CHIs based on the common intervention.关键词
中药注射剂/长春瑞滨/顺铂/非小细胞肺癌/网状Meta分析Key words
Chinese traditional medicine injection/Vinorelbine/Cisplatin/Non small cell lung cancer/Network Meta-analysis分类
医药卫生引用本文复制引用
田金徽,赵晔,李金龙,葛龙,杨克虎..10种中药注射剂联合长春瑞滨+顺铂化疗方案治疗非小细胞肺癌的网状Meta分析[J].中国药物评价,2015,(1):45-49,5.基金项目
甘肃省循证医学与临床转化重点实验室开放基金 （）
