摘要
Abstract
Objective:To assess the efficacy and safety of atomoxetine hydrochloride in the treatment of attention deficit hyperactivity disorder( ADHD).Methods: 7 comparative studies of tomoxetine hydrochloride in the treatment of ADHD were analyzed by Meta-analysis.Results:A total of 7 RCTs were included.The sample size was 1304 patients.Results of Meta-analysis showed that the im-provement of ADHD-RS[MD=-5.86,95%CI( -7.73,-3.99),P<0.00001]、ADHD-RS hyperactivity/impulsive[MD=-2.64, 95%CI(-3.75,-1.52),P<0.00001],ADHD-RS inattention[MD=-2.35,95%CI( -3.87,-0.83),P<0.00001]in atomoxetine hydrochloride group were significantly greater than in control group.The incidence of abdominal pain,nausea,somnolence,decreased appe-tite and vomiting in atomoxetine group were higher than in control group ( P<0.05).Conclusion:Atomoxetine is effective in the treat-ment of children with ADHD and can improve hyperactivity/impulsivity and attention deficit in children with ADHD.But the side effects of them should be considered.关键词
盐酸托莫西汀/儿童/注意缺陷多动障碍/Meta分析Key words
Atomoxetine hydrochloride/Children/Attention deficit hyperactivity disorder/Meta-analysis分类
医药卫生
